Mechanistic aspects of mineralocorticoid receptor activation
نویسندگان
چکیده
منابع مشابه
Mineralocorticoid receptor activation and oxidative stress.
The spontaneously hypertensive rat (SHR) has been extensively used in studies of hypertension for decades. More recently, a leptin receptor– deficient SHR (SHR/ NDmer-cp; SHR/cp) has been developed as a model for the human metabolic syndrome, characterized by elevated blood pressure, visceral obesity, glucose intolerance, and dyslipidemia. In this issue of Hypertension Nagase et al1 have used t...
متن کاملMineralocorticoid receptor activation promotes vascular cell calcification.
OBJECTIVE Clinical studies demonstrate that mineralocorticoid receptor (MR) antagonism improves outcomes in cardiovascular patients and that vascular calcification correlates with adverse cardiac events. We have recently demonstrated that human vascular smooth muscle cells (VSMCs) express functional MRs that, in response to aldosterone, modulate expression of osteogenic genes including alkaline...
متن کاملMineralocorticoid receptor activation and mineralocorticoid receptor antagonist treatment in cardiac and renal diseases.
C ardiac and renal diseases remain major challenges for healthcare systems in developed countries and commonly coexist, with a disorder in the heart or kidney often leading to secondary dysfunction or injury in the other organ. Indeed, the term cardiorenal syndrome has been introduced to describe the broad spectrum of disease involving both the heart and kidneys. 1 Aldosterone is a steroid horm...
متن کاملMultiple aspects of mineralocorticoid selectivity
Farman, Nicolette, and Marie-Edith Rafestin-Oblin. Multiple aspects of mineralocorticoid selectivity. Am J Physiol Renal Physiol 280: F181–F192, 2001.—Aldosterone regulates renal sodium reabsorption through binding to the mineralocorticoid receptor (MR). Because the glucocorticoid receptor (GR) is expressed together with the MR in aldosterone target cells, glucocorticoid hormones bound to GR ma...
متن کاملMultiple aspects of mineralocorticoid selectivity.
Aldosterone regulates renal sodium reabsorption through binding to the mineralocorticoid receptor (MR). Because the glucocorticoid receptor (GR) is expressed together with the MR in aldosterone target cells, glucocorticoid hormones bound to GR may also intervene to modulate physiological functions in these cells. In addition, each steroid can bind both receptors, and the MR has equal affinity f...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2000
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2000.00958.x